Role of Bile in Regulating Small RNAs in Salmonella typhi A Factor for Chronic Infection within Gallbladder?

Small non-coding RNAs have been shown to regulate mechanisms within bacteria required for their survival and adaptation (Wassarman, 2002; Repoila et al., 2003; Waters and Storz, 2009). These sRNAs interact directly with the protein or base pair with target mRNA to alter their activity (Wagner et al., 2002; Tjaden et al., 2006; Sharma and Vogel, 2009). The targets for many sRNAs are yet to be identified, but some function as a response to stress which alters membrane structure and general stress responses in bacteria (Gottesman et al., 2006; Guillier et al., 2006). The importance of understanding such a regulation is when organisms like S. typhi are able to survive within gallbladder-a site for storage of bile (Hazrah et al., 2004; Nath et al., 2008). Human bile possesses detergent like properties being bactericidal and sterile ISSN: 2319-7706 Volume 4 Number 2 (2015) pp. 183-197 http://www.ijcmas.com